English Translation of the abstract:
Methylmercury (MeHg) has cytotoxic effects in animals and humans and an important target for MeHg is the central nervous system (CNS). It is known that the developing CNS is very vulnerable to changes induced by MeHg compared to the mature brain. Most studies have focused on the direct effects of high doses of prenatal MeHg. Surprisingly, the effects on the behavior of adult mice exposed prenatally to the neurotoxic effects of low doses of mercury, so more like chronic ingestion in humans are not well studied. The objective of this study was to determine if such exposures produce adverse effects on the behavior of adult mice, including motor function and coordination, oral activities and memory. Fetuses were exposed in utero during gestation day 8 to day 18 by giving pregnant females C57B1/6J a diet containing MeHg at a daily dose of 0.01 mg / kg. Adult mice exposed prenatally to MeHg showed deficiencies in their ability to motor coordination, as well as all their activities, as measured by rotarod, analyzing it and open fields. Moreover, mice exposed to MeHg had a reference memory impaired, but not visible in the version of the Morris water maze. These results indicate that prenatal exposure to lower doses of MeHg examined to date may have lasting effects on cognitive and motor development into adult mice. These findings have important implications on the levels of MeHg deemed safe, especially during pregnancy, and increased rates of cognitive and psychological (eg Troubles of attention deficit hyperactivity disorder, autism) in our society .
Chronic, low-dose prenatal exposure to Méthylmercure odd motor and mnemonic function in adult mice C57/B6.
Montgomery KS, Mackey J , Thuet K, S Ginestra , Bizon JL , Abbott LC .
Department of Psychology, Texas A&M University, College Station, TX 77843-4235, USA.
Methylmercury (MeHg) has cytotoxic effects on animals and humans, and a major target organ for MeHg is the central nervous system (CNS). It is well known that the developing CNS is extremely vulnerable to MeHg-induced changes in comparison to the mature brain. Most studies have concentrated on the direct effects of high levels of prenatal MeHg exposure. Surprisingly, behavioral outcomes found in adult offspring exposed developmentally to the neurotoxic effects of chronic, low-dose mercury more akin to ingestion in humans are not well characterized. The objective of this study was to determine whether such exposure produces deleterious effects on behavior in adult mice, including motor/coordination abilities, overall activity and mnemonic function. Developing mouse fetuses were exposed in utero during gestational days 8-18 by giving pregnant C57Bl/6J female mice food containing MeHg at a daily dose of 0.01mg/kg body weight. Adult mice prenatally exposed to MeHg exhibited significant deficits in motor abilities, coordination, and overall activity, as measured by rotarod, footprint analysis and open field. In addition, MeHg-exposed mice were impaired with respect to reference memory but not in a visible, cued version of the Morris water maze task. These results indicate that prenatal exposure to the lowest dose of MeHg examined to date can have long-lasting motor and cognitive consequences on adult offspring. These findings have far reaching implications related to putative safe levels of MeHg ingestion, particularly during pregnancy, and increasing rates of cognitive and psychological disorders (e.g. attention hyperactivity deficit disorder, autism) in our society.
PMID: 18436314 [PubMed - as supplied by publisher]
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