Summary article, translated from English:
levels of pesticides are detectable in the residences located near agricultural fields.
Objective: Our aim was to evaluate the hypothesis that the mother's residence near a site where agricultural pesticides are applied during key periods of gestation may be associated with the development of autism in children.
Methods: We identified 465 children with autism born between 1996 and 1998 using the electronic files of the Development Services Department in California, and we have compared by date of last menstrual period of 6975 children born alive to normal weight and arrived in time, used as controls. We determined the proximity to areas of pesticide use records of Pesticides Regulations of the Department of California records refined using Department of Water Resources. An analytical scheme using a priori criteria conditional logistic regression was used to exclude associations related to multiple testing errors.
Results: Of 249 unique hypotheses, four that described the organochlorine pesticide applications, especially dicofol and endosulfan, which the exhibition took place immediately before and during embryogenesis (clinical weeks 1 through 8) central nervous system have responded to a priori criteria and could hardly be the result of multiple testing. multiple variants of a posteriori models comparing children of mothers living at 500 m from sites with the highest concentration of organochlorine those mothers not living near these sites gave a ratio of 6.1% Autism (95% confidence interval, 2.4-15.3). The risk of autism increased with doses of organochlorine use and decreased with distance from these sites.
Conclusions. The association between residential proximity to applications organochlorine pesticides during pregnancy and autism in children should be better studied.
Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders Among Children in the California Central Valley
Eric M. Roberts, 1 Paul B. English, Judith K. 2 Grether, Gayle C. 2 Windham, Lucia Somberg 2, 3 and Craig Wolff 2
Background. Ambient levels of pesticides (“pesticide drift”) are detectable at residences near agricultural field sites.
Objective. Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism spectrum disorders (ASD) in children.
Methods. We identified 465 children with ASD born during 1996–1998 using the California Department of Developmental Services electronic files, and matched them by maternal date of last menstrual period to 6,975 live-born, normal-birth-weight, term infants as controls. We determined proximity to pesticide applications using California Department of Pesticide Regulation records refined using Department of Water Resources land use polygons. A staged analytic design applying a priori criteria to the results of conditional logistic regressions was employed to exclude associations likely due to multiple testing error.
Results. Of 249 unique hypotheses, four that described organochlorine pesticide applications—specifically those of dicofol and endosulfan—occurring during the period immediately before and concurrent with central nervous system embryogenesis (clinical weeks 1 through 8) met a priori criteria and were unlikely to be a result of multiple testing. Multivariate a posteriori models comparing children of mothers living within 500 m of field sites with the highest nonzero quartile of organochlorine poundage to those with mothers not living near field sites suggested an odds ratio for ASD of 6.1 (95% confidence interval, 2.4–15.3). ASD risk increased with the poundage of organochlorine applied and decreased with distance from field sites.
Conclusions. The association between residential proximity to organochlorine pesticide applications during gestation and ASD among children should be further studied.
L’article complet se trouve :
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17938740
0 comments:
Post a Comment