Wednesday, May 21, 2008

How Did Kimberly Bergalis Contract Aids?

Exposure of newborns to thimerosal and developmental disorders

Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink.

The George Washington University School of Public Health and Health Services, Department of Epidemiology and Biostatistics, United States.

The study evaluated possible associations between neurodevelopmental disorders (NDs) and exposure to mercury (Hg) from Thimerosal-containing vaccines (TCVs) by examining the automated Vaccine Safety Datalink (VSD). A total of 278,624 subjects were identified in birth cohorts from 1990-1996 that had received their first oral polio vaccination by 3 months of age in the VSD. The birth cohort prevalence rate of medically diagnosed International Classification of Disease, 9th revision (ICD-9) specific NDs and control outcomes were calculated. Exposures to Hg from TCVs were calculated by birth cohort for specific exposure windows from birth-7 months and birth-13 months of age. Poisson regression analysis was used to model the association between the prevalence of outcomes and Hg doses from TCVs. Consistent significantly increased rate ratios were observed for autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances with Hg exposure from TCVs. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs. Routine childhood vaccination should be continued to help reduce the morbidity and mortality associated with infectious diseases, but efforts should be undertaken to remove Hg from vaccines. Additional studies should be conducted to further evaluate the relationship between Hg exposure and NDs.

PMID: 18482737 [PubMed - as supplied by publisher]

L'article se trouve : http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T06-4SHFSVN-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d53912fee9bc24df9876b305a02cc114


Tuesday, May 20, 2008

Perth Gay Pickup Spots

The immune response in autism: a new frontier of research

The immune response in autism: a new frontier for autism research

Paul Ashwood *, 1 , Sharifia Wills {dagger} andJudy Van de Water

Full article at:
http://www.jleukbio.org/cgi/content/full/80/1/1


extract, translated from English

Autism spectrum disorders (BP) are among the pervasive developmental disorders that develop during childhood. They are characterized by disturbances in social interaction, verbal and nonverbal behaviors and the presence of stereotyped and repetitive. Currently, the etiology of TA is largely unknown, but it is thought that genetic factors, environmental, immune and neurological play a role in the development of TA. Recently, more and more researches have focused on the connection between the immune and nervous system, including its role possible in the development of TA. These neuroimmune interactions begin early during embryogenesis and persist throughout the life of the individual, a normal neurological development is dependent upon an appropriate immune response. Immune aberrations consistent with a dysregulation of the immune response, which were previously reported in autistic children included abnormal levels of T cell type 1 T H 1) / T H 2 cytokine profiles, the lower levels of lymphocyte, T cell mitogen response, and an abnormal level of serum immunoglobulin. Furthermore, the autistic was associated with autoimmunity and an association with genes such as leukocyte antigens (HLA)-DRB1 and complement C4 alleles described. It is possible that such aberrant immune activity during vulnerable and critical periods of neurodevelopment could participate in the generation of neurological dysfunction characteristic of TA. This paper will review the status of research linking the immune response and autism.

CONCLUSIONS:

TAs are a very heterogeneous group of disorders with multiple phenotypes and subgroups that share common behavioral abnormalities. This inherent complexity has made it extremely difficult to understand the etiology of LD. Among the literature describing studies on the immunology of TA, there are many differences and unconfirmed reports. Many studies report apparently conflicting results, and to date, no consensus with respect to disorders of the immune system could not be found. However there are reports of increasing number of immune dysfunction in autism, there is a growing awareness that immune dysfunction may to play a role at least one (of the) subgroup (s) of autistic patients, if not all. In addition, various hypotheses have tried to link the activity of immune dysfunction and autism, such as abnormalities of the immune system of the mother in early pregnancy, an increased incidence of autoimmunity in families, childhood immunizations, and the generation of animal models based on immune parameters. A clear definition of the sub-groups of patients with LD using modern diagnostic tools may help to better define the results of these studies. The neurological and immune system are inextricably related to early embryo development. Abnormalities of the immune system before or during birth are capable of altering levels of cytokines, chemokines, neurotransmitters, neuropeptides, as well as hormone levels. Each of these substances influence the course of dévellopement nervous system and / or immune directly or through secondary actions. A development of the disturbances can be the beginning of a continuous cycle of damage and disruption of both systems. There are many pathways that can lead to the diagnosis of autism. For some it may begin with a genetic susceptibility, and for others infection or abnormalities of the immune system may play a key role. Further studies on the interactions of the nervous system, immune and endocrine systems may help unravel the mystery of autism. [...]


Original in English:


ABSTRACT


Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped behaviors. At the present time, the etiology of ASD is largely unknown, but genetic, environmental, immunological, and neurological factors are thought to play a role in the development of ASD. Recently, increasing research has focused on the connections between the immune system and the nervous system, including its possible role in the development of ASD. These neuroimmune interactions begin early during embryogenesis and persist throughout an individual’s lifetime, with successful neurodevelopment contingent upon a normal balanced immune response. Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (T H 1)/T H 2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described. There is potential that such aberrant immune activity during vulnerable and critical periods of neurodevelopment could participate in the generation of neurological dysfunction characteristic of ASD. This review will examine the status of the research linking the immune response with ASD.

Key Words: autism spectrum disorder (ASD) • neurodevelopment • neurokine • immunity • inflammation • cytokines

CONCLUSION


The ASD are an extremely heterogenous group of disorders with multiple phenotypes and subgroups that share behavioral commanalities. This inherent complexity has made deciphering the etiology of the broad spectrum of ASD extremely difficult. Within the literature describing immune-based studies in ASD, there are a number of discrepancies and unreplicated reports. Numerous studies report apparently conflicting results, and thus far, no consensus about the described immune findings has been reached. However, with increasing reports of immune dysfunction in autism, there is a growing awareness and concern that immune dysfunction may play a role in, if not all, at least a subgroup(s) of patients with autism. Moreover, various hypotheses have attempted to link dysfunctional immune activity and autism, such as maternal immune abnormalities during early pregnancy, increased incidence of familial autoimmunity, childhood vaccinations, and the generation of autism animal models based on immune parameters. A clear-cut definition of the groups or subgroups of ASD patients using modern diagnostic tools may help to better define these study results. The neurological and immune systems are inextricably intertwined beginning in the embryonic stage of life. Pre- or perinatal immune dysregularities are capable of altering levels of cytokines, chemokines, neurotransmitters, neuropeptides, as well as hormones. Each of these substances may influence the course of development in the nervous and/or immune systems primarily or through secondary action. A development perturbation may be the beginning of a continual cycle of damage or disruption to both systems. There are numerous pathways that may lead to the diagnosis of ASD. In some, it may begin with genetic susceptibility, and in others, infection or immune abnormalities may play a key role. Further study of the reciprocal actions of the nervous, immune, and endocrine systems may help to unravel the mystery of ASD. Moreover, while the extent to which many of the observations discussed herein are involved in the pathogenesis of autism is unknown, it cannot be discounted that immune dysfunction is an epiphenomenon or a consequence of the disease. Comprehensive studies of autism and age-matched control individuals and their families are necessary for more conclusive results.


Thursday, May 15, 2008

Masterbate With Sneakers

Changing the course of autism

Changing the Course of Autism: A Scientific Approach for Parents and Physicians (Broché)




de Bryan Jepson (Auteur), Jane Johnson (préface)

Descriptions du produit

Bryan Jepson is a doctor .. father of an autistic child. When her child was diagnosed with autism, he initially reacts as a doctor "classical" thinking there was no coming. Until the day his wife wanted to try the diet free from gluten and casein. While believing that the thing was devoid of interest, he let him into thinking that this would ease the mother who would feel like something useful for his son, and that as long as it kept a balanced diet, it could not hurt her son.

What has not been his surprise when he saw his son actually progress. He then better informed, was to see the DAN doctors, he was able to judge the seriousness of the methods, and it gradually formed itself to this one in order to treat his son. He then changed his medical practice and opened an office to deal with other children and then to join an existing practice using the methods of DAN. He has already treated hundreds of children when he wrote this book.

There's a few decades, autism was a rare disease now, most Americans know a family with an autistic child. There is an epidemic of autism, which affects half a million American children, or one in 150.
This makes the disorder most current developments. Autism increased from 10 to 17% per year, which means that the disease could reach millions of people within the next decade. Change the course of autism can potentially revolutionize the way the disease is seen by showing that it can be treated as such, rather than see it as a disability or a genetic defect against which nothing can.

The author explains in this book is very detailed and scientific causes of autism and treatment options, Referring to the numerous scientific studies conducted to date.

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To finish with Pasteur: A century of scientific hoax




of Dr. Eric Ancelet (Author)

Product Description
Presentation Editor
Initially, the author discusses the Pasteur's work by showing the flaws and mistakes of his research. Then he studies the real effects of various vaccines, the dangers, the phasing of our natural defense systems. Finally, it addresses issues ethical, political, economic, social and biological excessive vaccination. - 16 x 24
Paperback - 270 pages + CD audio interviews of 60 minutes

Author Biography
DVM, Psychotherapist, author and lecturer, Eric ANCELET is primarily an independent investigator looking for "holy comfortable ". "Health primate, a fundamental concept proposed by Dr Michel Odent is now central to his concerns as a therapist: the genesis and maintenance of health go through a thorough reflection on childhood, including avoidance multiple assaults during this critical period from conception to around seven years.

Wednesday, May 14, 2008

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Using acetaminophen ( paracetamol), the MMR vaccine and autism. Result of a survey of parents.

www.project


The current study was conducted to determine whether the use of acetaminophen after MMR vaccination may be associated with autism. This controlled study used the results of an Internet questionnaire conducted among parents of 16 July 2005 to January 30, 2006, consist of 83 children with autism against 80 controls. Acetaminophen use after MMR was significantly associated with autism in children 5 years old (OR 6.11, 95% CI 1.42-26.3), after limiting cases of children who regressed (OR 3.97, 95% CI 1.11-14.3) and considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56-43.3), adjusting for age, sex, ethnicity of the mother and the presence of concurrent disease with the MMR vaccine. Ibuprofen use after the MMR vaccine was not associated with autism. This preliminary study shows that use of acetaminophen after vaccination MMR was associated with autism.

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey.

Schultz ST, Klonoff- Cohen HS, Wingard DL , Akshoomoff NA, Macera CA , Ming Ji .

University of California San Diego, and San Diego State University, USA. Stephen.schultz@med.navy.mil.

The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder. This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42-26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11-14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56-43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.

PMID: 18445737 [PubMed - in process]

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Autism: a genetic fate? : The investigation of a mother of Truths




de Marie-Christine Dépréaux (Auteur)

Product Description
Presentation Editor
mother of three whose eldest is autistic, Marie-Christine Dépréaux spends most of his time to research, analyze and translate everything for 8 years, relates to biomedical approaches to autism, leading to an acceptable level of scientific quality and support by solid medical references and especially to go through. If
English literature on this view of autism is abundant evidence of many parents and physicians, if discussions are held as well at the government level as English-language media both radio and television, nothing similar exists for a francophone audience.
is why she decided to venture into the book because she would have liked to see 20 years ago, provoking serious debates and providing discounts on the subject.
She finally rebelled against the immutable speech and heard too often fatalistic about autism: genetic inevitability, no! Too simplistic!
It reveals that there is a microcosm medical cause of new biomedical approaches to autism.
hope that members of the DAN (Defeat Autism Now) are those scientific avant-garde, with the assistance of parents of autistic children, wake up the sleeping science community to defeat autism for those already affected and to determine its origin to prevent further victims.

"Some scientists have peace of mind (they believe) they know and are continuing their work and lessons in the comfort of dogmatic slumber. If one looks at the history of science, their position is not necessarily legitimate. "

Growth Behind In The Eye

Autism and Vaccination: Responsible but not guilty




Sylvie Simon

Product Description

Autism has become the new epidemic of the century, but the Government claims that its origin is genetic. How a genetic disease can it have multiplied by 12 in ten years in developed countries? This growth can no longer be due to misdiagnosis in the past, as some claim, because in this case, which are now autistic from over twenty years? Autism affects probably those with genetic predisposition, but to thrive, the disease requires a detonator, and vaccines can play this role in the explosion of the disease. The idea of associating autism and vaccines is still unpopular, however, this hypothesis is gaining ground because about 50% of parents of autistic children report that their child's behavior changed immediately after vaccination. Sylvie Simon has conducted a survey of many doctors, virologists and immunologists international. They are certain that many cases are essentially within the intensive vaccination of children and that it will get worse when hundreds of thousands of children become adults. This book is for parents who want to compare the benefits of vaccines including their misdeeds regarding autism. It is also for parents whose children are already autism by demonstrating that autism is not a condemnation and it is possible to improve and even cure these children.

Tuesday, May 13, 2008

Where Is Mapouka From

Vaccinations

I should come back repeatedly vaccinations is a very controversial topic (for autism, as with other diseases). Mercury (and other adjuvant) has been implicated in autism, as well as the vaccine itself (research of Andrew Wakefield MMR), a book to read on this subject is: "What Your Doctor May Not Tell you about children's vaccinations "by Stephanie Cave.



For now here are 2 interesting sites :

http://www.tinussmits.com/english/ : The site of Tinus Smits, a Dutch who developed a homeopathic method for treating post-vaccination syndrome (a PDF version of his method is available on his site)

http://www.jelmiger.com/ : Sequential Homeopathy, developed by Jean Elmiger, a Swiss doctor who wrote: "Medicine found, or, The new ambitions of homeopathy " a homeopathic method which seems to follow the same principle as that of Tinus Smits, but more complex. The website indicates the homeopathic practitioner this method in all of France.


Saturday, May 10, 2008

Is Marihuana Good For Tendonitis

Here's the long awaited day has arrived! Back in Canada


We had to leave Guinea earlier to experience this great event.

Cheryl went to 39 weeks of pregnancy!

Our little boy, Simon Girard Czar (Czar means Tanda first boy) was born Friday, May 2 at 6:58 am. He was doing very well from his birth he weighed 7 pounds 4 ounces and measured 19.5 inches.

The labor lasted over 30 hours ... Then there were complications for the mother. Cheryl is anemia and we have both mononucleosis. The priority is to adapt to Simon and get some rest.

However, we are in joy and we take the opportunity to smooch from head to feet, the stick and we exclaim at each new movement!

We also want to mark the arrival of his cousin Theo. He was born a few hours after Simon, is May 3 It's a nice little treasure. Renee and Mike are doing well despite the fatigue.

Thanks again for all your support, nice shower, your encouragement and your prayers. THANK YOU!

"From the womb of my mother I rely on you;
It was you who made me out of the womb;
You are always the object of my praise.
I am for many as a prodigy ... "
Psalms 71: 6-7

Thank you Lord for this great Simon!
You have answered our prayers.

PS We have new Photo (left menu).

Friday, May 9, 2008

Invader Zim Someone Needs A Hug

Residence of mothers near agricultural areas are used pesticides and autism among children in the Central Valley of California


Summary article, translated from English:

levels of pesticides are detectable in the residences located near agricultural fields.

Objective: Our aim was to evaluate the hypothesis that the mother's residence near a site where agricultural pesticides are applied during key periods of gestation may be associated with the development of autism in children.

Methods: We identified 465 children with autism born between 1996 and 1998 using the electronic files of the Development Services Department in California, and we have compared by date of last menstrual period of 6975 children born alive to normal weight and arrived in time, used as controls. We determined the proximity to areas of pesticide use records of Pesticides Regulations of the Department of California records refined using Department of Water Resources. An analytical scheme using a priori criteria conditional logistic regression was used to exclude associations related to multiple testing errors.

Results: Of 249 unique hypotheses, four that described the organochlorine pesticide applications, especially dicofol and endosulfan, which the exhibition took place immediately before and during embryogenesis (clinical weeks 1 through 8) central nervous system have responded to a priori criteria and could hardly be the result of multiple testing. multiple variants of a posteriori models comparing children of mothers living at 500 m from sites with the highest concentration of organochlorine those mothers not living near these sites gave a ratio of 6.1% Autism (95% confidence interval, 2.4-15.3). The risk of autism increased with doses of organochlorine use and decreased with distance from these sites.

Conclusions. The association between residential proximity to applications organochlorine pesticides during pregnancy and autism in children should be better studied.

Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders Among Children in the California Central Valley

Eric M. Roberts, 1 Paul B. English, Judith K. 2 Grether, Gayle C. 2 Windham, Lucia Somberg 2, 3 and Craig Wolff 2

Background. Ambient levels of pesticides (“pesticide drift”) are detectable at residences near agricultural field sites.

Objective. Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism spectrum disorders (ASD) in children.

Methods. We identified 465 children with ASD born during 1996–1998 using the California Department of Developmental Services electronic files, and matched them by maternal date of last menstrual period to 6,975 live-born, normal-birth-weight, term infants as controls. We determined proximity to pesticide applications using California Department of Pesticide Regulation records refined using Department of Water Resources land use polygons. A staged analytic design applying a priori criteria to the results of conditional logistic regressions was employed to exclude associations likely due to multiple testing error.

Results. Of 249 unique hypotheses, four that described organochlorine pesticide applications—specifically those of dicofol and endosulfan—occurring during the period immediately before and concurrent with central nervous system embryogenesis (clinical weeks 1 through 8) met a priori criteria and were unlikely to be a result of multiple testing. Multivariate a posteriori models comparing children of mothers living within 500 m of field sites with the highest nonzero quartile of organochlorine poundage to those with mothers not living near field sites suggested an odds ratio for ASD of 6.1 (95% confidence interval, 2.4–15.3). ASD risk increased with the poundage of organochlorine applied and decreased with distance from field sites.

Conclusions. The association between residential proximity to organochlorine pesticide applications during gestation and ASD among children should be further studied.

L’article complet se trouve :

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17938740

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Chronic exposure to low doses of methylmercury fetus deteriorates motor function and memory in mice C57/B6 adults

English Translation of the abstract:



Methylmercury (MeHg) has cytotoxic effects in animals and humans and an important target for MeHg is the central nervous system (CNS). It is known that the developing CNS is very vulnerable to changes induced by MeHg compared to the mature brain. Most studies have focused on the direct effects of high doses of prenatal MeHg. Surprisingly, the effects on the behavior of adult mice exposed prenatally to the neurotoxic effects of low doses of mercury, so more like chronic ingestion in humans are not well studied. The objective of this study was to determine if such exposures produce adverse effects on the behavior of adult mice, including motor function and coordination, oral activities and memory. Fetuses were exposed in utero during gestation day 8 to day 18 by giving pregnant females C57B1/6J a diet containing MeHg at a daily dose of 0.01 mg / kg. Adult mice exposed prenatally to MeHg showed deficiencies in their ability to motor coordination, as well as all their activities, as measured by rotarod, analyzing it and open fields. Moreover, mice exposed to MeHg had a reference memory impaired, but not visible in the version of the Morris water maze. These results indicate that prenatal exposure to lower doses of MeHg examined to date may have lasting effects on cognitive and motor development into adult mice. These findings have important implications on the levels of MeHg deemed safe, especially during pregnancy, and increased rates of cognitive and psychological (eg Troubles of attention deficit hyperactivity disorder, autism) in our society .

Chronic, low-dose prenatal exposure to Méthylmercure odd motor and mnemonic function in adult mice C57/B6.

Montgomery KS, Mackey J , Thuet K, S Ginestra , Bizon JL , Abbott LC .

Department of Psychology, Texas A&M University, College Station, TX 77843-4235, USA.

Methylmercury (MeHg) has cytotoxic effects on animals and humans, and a major target organ for MeHg is the central nervous system (CNS). It is well known that the developing CNS is extremely vulnerable to MeHg-induced changes in comparison to the mature brain. Most studies have concentrated on the direct effects of high levels of prenatal MeHg exposure. Surprisingly, behavioral outcomes found in adult offspring exposed developmentally to the neurotoxic effects of chronic, low-dose mercury more akin to ingestion in humans are not well characterized. The objective of this study was to determine whether such exposure produces deleterious effects on behavior in adult mice, including motor/coordination abilities, overall activity and mnemonic function. Developing mouse fetuses were exposed in utero during gestational days 8-18 by giving pregnant C57Bl/6J female mice food containing MeHg at a daily dose of 0.01mg/kg body weight. Adult mice prenatally exposed to MeHg exhibited significant deficits in motor abilities, coordination, and overall activity, as measured by rotarod, footprint analysis and open field. In addition, MeHg-exposed mice were impaired with respect to reference memory but not in a visible, cued version of the Morris water maze task. These results indicate that prenatal exposure to the lowest dose of MeHg examined to date can have long-lasting motor and cognitive consequences on adult offspring. These findings have far reaching implications related to putative safe levels of MeHg ingestion, particularly during pregnancy, and increasing rates of cognitive and psychological disorders (e.g. attention hyperactivity deficit disorder, autism) in our society.

PMID: 18436314 [PubMed - as supplied by publisher]

L’article complet se trouve :

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYP-4S2MHTB-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee0be7e202d2646f66d213af6ea67abc

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folic acid and treatment of some cases of autism

Translated from English (see below). Summary Brief

Autoimmunity folate receptor and folate deficiency brain in autism with low-level neurological deficits

reduced folate transport to the central nervous system was identified for two autistic disorder: the Rett syndrome and infantile autism with low-level neurological deficits.
Twenty five patients with low-level autism at birth, with and without neurological deficit, had their rates folate in serum, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies blocking type evaluated to determine the importance of folate receptor autoantibodies (FR) relative to transport folate across the blood-brain barrier. Despite normal levels of folate in serum, CSF-5MTHF was down to 23 of these 25 patients. The reduced rate of folate in CSF in 19 of the 23 patients could be explained by the serum EN autianticorps blocking the folate binding site of BF attached to membranes on the choroid epithelial cells. Oral supplementation with folic acid has led normalization of CSF 5MTHF and partial or total recovery after 12 months. The autoimmunity in serum FR appears to represent an important factor in the pathogenesis of reduced folate transport to the nervous system of children with autism early low or not associated with neurological deficits. The detection of autoantibodies FR can be a key factor in the prevention and therapy of this subgroup of patients.

My comment: The medical terminology is not very clear to me (I hope the translation is almost correct) but in any case one thing is clear: a sub group of autism or autism some low-level non-regressive and some Rett syndrome, is due to autoantibodies GB and can be treated by simple supplementation with folic acid (I guess if the child is complemented in time before damage to its development are irreversible). Maybe in some years this test could be made standard at birth, like PKU, preventing some cases of autism.

Neuropediatrics. 2007 Dec; 38 (6) :276-81.

Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.

Ramaekers VT , Blau N , Sequeira JM , Nassogne MC , Quadros EV .

1Division of Child Neurology, University Hospital Liège, Belgium.

Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with early-onset low-functioning autism with or without neurological deficits, were evaluated for serum folate, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies of the blocking type to determine the significance of folate receptor (FR) autoantibodies with respect to folate transport across the blood-CSF barrier. In spite of normal serum folate, CSF 5MTHF was low in 23 of 25 patients. The reduced CSF folate in 19 of these 23 patients could be explained by serum FR autoantibodies blocking the folate binding site of the membrane-attached FR on the choroid epithelial cells. Oral folinic acid supplements led to normal CSF 5MTHF and partial or complete clinical recovery after 12 months. Serum FR autoimmunity appears to represent an important factor in the pathogenesis of reduced folate transport to the nervous system among Children with early-onset low-functioning autism associated With or Without Neurological deficits. Early detection of autoantibodies FR May Be A Key Factor In The Prevention and Therapeutic Intervention Among this subgroup of patients With autism.

PMID: 18461502 [PubMed - in process]

Wednesday, May 7, 2008

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Children and autism

Children and Autism - part 2

Full article in pdf format at:

http://www.racgp.org.au/afp/ 200710/19850

The article is written by Manya Angley, a professor at the School of Pharmacy and Medical Sciences Australia

It is neither for nor against alternative approaches to treatment of autism, but an update of research conducted (date of article October 2007).

The Complementary and Alternative Medicine (Complementary and alternative medicines (CAMs)) and diets are widely used in children with autism, by approximately 50% of families (in the U.S. and Australia) because the treatments offered by pharmaceutical traditional medicine are limited and often accompanied by significant adverse effects.

She made a point not exhaustive of the different approaches and the few scientific studies on them.

B6 and magnesium
Study of Kuriyama et al (for each study is given in the bibliography section) comparing pyridoxine against a placebo showed an improvement in verbal IQ in the treated group, whereas other studies (Findling et al and Tolbert et al) n have not found significant differences. Vitamin C


A small double-blind study showed a decrease of stereotyped behaviors in children receiving vitamin C.

DMG
Two double-blind studies showed no difference between the group taking the DMG and it did not.

Omega 3 and omega 6
Study and case control comparative study showed no benefit from the use of fatty acids in children with autism. Melatonin


Paavonen et al found a significant reduction of time required to sleep in children taking melatonin (study on 15 children with autism)

Probiotics
Although no study has been published on the use of probiotics in autistic children, they can be used to restore the balance of intestinal flora and reduce bacteria produce toxins that can contribute to their problems bowel. Vitamin B12


James et al conducted a study in which they were administered intravenous doses of vitamin B12 in 8 children with autism had abnormal levels of metabolites in the methionine cycle. This
supplementation, cut to a folic acid and betaine restored the normal level of these metabolites in these children.

Diets
Two studies on diet without gluten and casein have been made, with conflicting results. Knivsberg et al found significant improvements while Elder et al found no improvement.
Other systems are used, but studies have yet been made. More controversial treatments


A single study on the use of TTFD was performed with a low number of children, indicating an improvement. Other forms of chelation have not been studied scientifically.
Studies have been made showing evidence of zinc deficiency in some children with autism. Yorbik et al have found zinc levels significantly lower than in healthy controls. Zinc has a role in the immune system, production of neurotransmitters and antioxidant properties.



Conclusions The conclusions of the author of the article is that autism is a chronic disorder for which there is currently no cure and it became the target of non-conventional treatments. Often disenchanted with traditional medicine that seems to do little to help their child, parents are turning to alternative medicines and diets. It is important to discuss these alternative therapies with them openly and with compassion (my comment: if the French doctors could do in their majority ... at least that). Although must take into account the emotional, financial and time of intervention if they do no harm to the child, there may be benefits, particularly if interventions are implemented with educational support or other structured behavioral and educational interventions. However large double blind studies are still lacking to assess the effectiveness of most of these interventions.

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nutritional therapies for mental disorders

Lakhan SE, Vieira KF. J. Nutr
2008 Jan 21; 7:2. The whole article is available free at:
http://www.nutritionj.com/content/7/1/2
PMID: 18208598 [PubMed - indexed for MEDLINE]

Translation from English (the summary section only)
According to the Diagnostic and Statistical Manual of Mental Disorders, 4 of the 10 leading causes of disability in the U.S. and other countries developed are mental disorders. Depression, bipolar disorder, schizophrenia and obsessive compulsive disorder are among the most common mental disorders that pose serious problems in many countries and have different degrees of impact, ranging from 26% in United States 4% China. Although part of this difference can be attributed to how the diagnosis of disorder mind is asked by doctors, it can also be explained by the lack of certain nutrients contributing to the development of mental disorders as shown in some studies. In particular, certain vitamins and minerals and omega-3 are often deficient in the population of United States and other countries develloped, and are particularly deficient in patients suffering from mental disorders. Studies have shown that daily supplementation with vital nutrients effectively reduces symptoms. Supplements that contain amino acids also reduce symptoms, because they are converted to neurotransmitters that reduce depression and other mental disorders. Based on emerging evidence, this form of nutritional therapy may be appropriate to control depression, bipolar disorder, schizophrenia, anxiety, eating disorders, attention deficit and attention deficit Hyperactivity Disorder (AD / ADHD), behavior Aditi and autism. The purpose of this study is to highlight what nutritional supplements can help treat the four most common mental disorders in the United States and other developed countries: depression, bipolar disorder, schizophrenia disorder and obsessive compulsive disorder. Most antidepressants and other drugs have significant side effects, which often discourages patients from taking them. Those patients who have mental disorders and are not treated are at high risk of suicide or institutionalization. One way for psychiatrists to deal with this problem is to educate on the usefulness of alternative therapies or nutritional. Although in the case of certain nutrients further research should be conducted to determine the recommended doses of most nutritional supplements, psychiatrists can recommend doses of dietary supplements en se basant sur les études précédentes et actuelles et ajuster ensuite en fonction des résultats obtenus.
Nutritional therapies for mental disorders.
Lakhan SE, Vieira KF.
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA. slakhan@gnif.org
According to the Diagnostic and Statistical Manual of Mental Disorders, 4 out of the 10 leading causes of disability in the US and other developed countries are mental disorders. Major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder (OCD) are among the most common mental disorders that currently plague numerous countries and have varying incidence rates from 26 percent in America to 4 percent in China. Though some of this difference may be attributable to the manner in which individual healthcare providers diagnose mental disorders, this noticeable distribution can be also explained by studies which show that a lack of certain dietary nutrients contribute to the development of mental disorders. Notably, essential vitamins, minerals, and omega-3 fatty acids are often deficient in the general population in America and other developed countries; and are exceptionally deficient in patients suffering from mental disorders. Studies have shown that daily supplements of vital nutrients often effectively reduce patients' symptoms. Supplements that contain amino acids also reduce symptoms, because they are converted to neurotransmitters that alleviate depression and other mental disorders. Based on emerging scientific evidence, this form of nutritional supplement treatment may be appropriate for controlling major depression, bipolar disorder, schizophrenia and anxiety disorders, eating disorders, attention deficit disorder/attention deficit hyperactivity disorder (ADD/ADHD), addiction, and autism. The aim of this manuscript is to emphasize which dietary supplements can aid the treatment of the four most common mental disorders currently affecting America and other developed countries: major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder (OCD).Most antidepressants and other prescription drugs cause severe side effects, which usually discourage patients from taking their medications. Such noncompliant patients who have mental disorders are at a higher risk for committing suicide or being institutionalized. One way for psychiatrists to overcome this noncompliance is to educate themselves about alternative or complementary nutritional treatments. Although in the cases of certain nutrients, further research needs to be done to determine the best recommended doses of most nutritional supplements, psychiatrists can recommend doses of dietary supplements based on previous and current efficacious studies and then adjust the doses based on the results obtained.

Tuesday, May 6, 2008

Can Yaz Work As A Morning After

Omega-3

Extrait de l'article paru dans : Biological psychiatry

Volume 61, Issue 4, Pages 551-553 (15 February 2007)

Traduit de l'anglais

Supplémentation en Omega 3 chez les autistic children: a double-blind, randomized, placebo-controlled

premise: more and more evidence suggests that deficiencies in Omega 3 can contribute to neurodévellopementaux disorders of childhood.

Method:

A randomized, double-blind, placebo-controlled study lasting six weeks was made to analyze the results of complementation of 1 .5 g of fatty acids (.84 g EPA and 0.7 g DHA) in 13 children (aged 5-17 years) with autism also suffering from severe behavioral disorders, aggression, or self-harm. The results were measured according to the ABC (Aberrant Behavior Checklist) after 6 weeks.

Results: We observed
an advantage to the group supplemented with omega 3 fatty acid compared to placebo for aggression and stereotypies. Repeated measures ANOVA showed a superiority of the group supplemented with omega-3 relative to placebo for hyperactivity. No negative effects were noted in the 2 groups.




Conclusions The results of this study provide preliminary evidence that omega 3 supplementation may be effective treatment for autistic children.

The article can be found at:

http://www.journals.elsevierhealth.com/periodicals/bps/article/S0006-3223 (06) 00591-9/abstract

Monday, May 5, 2008

A Speed Boat Is Being

"Dyslogic Syndrome" by Bernard Rimland




Jessica Kingsley Publishers, ISBN-10: 1843108771

Dr. Bernard Rimland was one of the founders of DAN and the founder of the ARI (Autism Research Institute) . Psychologists her son was diagnosed with autism in the 50's and he wrote in the 60 "Infantile Autism: The Syndrome and Its Implications for a Neural Theory of Behavior "which has revolutionized the way its time to see the autism theory of" frigid mother "was abandoned to consider autism as a neurological disorder. Hopefully this new book will cause a revolution too. But if one considers that the French doctors have over 40 years to understand that autism is not a psychological problem, we can wait a long time ...

The book does not speak specifically of autism actually or not just in any case. He speaks mainly of disorders more "minor" disorders such as behavioral or conduct disorders, hyperactivity attention deficit disorder, learning disorders, and also personality disorders most important such as autism or schizophrenia. Dr. Rimland provides a global name for all of these disorders: "the dyslogic syndrome" might be translated as the dyslogie. Does not speak one more step in addition to dyslexia, dyspraxia, dyscalculia, dysphasia? French doctors are even using the term "disharmony" (instead of saying high-functioning autism or Asperger). Rimland He invented a new term: dyslogie, which refers to all persons who do not behave logically, therefore, especially behavior problems.

The book is divided into two parts: the epidemic and dyslogie responsible dyslogie.

Part I: Outbreak of dyslogie

Chapter 1: What is dyslogie?

"It would have looked silly if I had the gun out and I had not shot him. I have looked stupid "is a typical example of reasoning dyslogique. Bernard Rimland

"invented" the term dyslogie in 1975 following the questioning of his friend John who was writing a Wacker essay about learning disabilities, and noted that many children who had problems in reading, math, writing was also a more serious problem: a problem of logical reasoning.

The biological basis of thought can easily malfunction: the brain is our most complex organ and it is also the most fragile: it is an easy target for all the toxins and accidents. By cutting the regular supply of nutrients to the brain by reducing its oxygen supply by reducing the supply of glucose, or the pollutant with heavy metals or chemicals, it malfunctioned.

Chapter 2: The victims of the epidemic dyslogie

Rimland cites several studies that show a deterioration in the grade level of students, an increase in conduct disorders in schools, emphasized by many teachers. While the number of autistic children has increased dramatically in recent years, this is not the only disease to have increased. Since the fifties, the percentage of children with physical or mental or learning disabilities has increased from 2% to 8%. About 4 million Americans suffer from schizophrenia or bipolar disorder, about 10 times in the last century. Approximately 150 000 children under 6 years are treated with antipsychotics or Ritalin!

The number of crimes committed without any logical reason is constantly increasing. Rimland cites the case of a child who had killed his mother after seeing American beauty because of the aesthetic representation of death in the film. He cites many other instances throughout the book, including cases of multiple murders in American schools, cases that are more and more often in the headlines.

In his 1975 book, John Walker had identified several evidence to recognize the dyslogie:

- misjudgment

- Failure to understand the consequences of their actions

- selfish or narcissistic behavior

- Impulsivity

- Inability to delay immediate gratification to achieve long-term goal

- Low level of attention

- catastrophic reactions and inappropriate for small problems

- Poor abstract thinking

- impoverished social skills and often poor visual contact with Other

- Lack of empathy towards others or animals

- Inability to learn through experience

- Need excessive exciting sensations

- Lack of inhibition and easily frustrated

Not only grades in general down, but even the cultural content of television broadcasts down (if not totally absent) to meet the needs of this growing population dyslogiques.

He cites a test taken in the early 1990s to test the writing skills of students in universities (colleges) U.S.: 4 / 10 of 1% have passed this test with a level regarded as the norm a few decades before (the rest were well on below).

Chapter 3: Why psychological interventions can not cure dyslogie

He cites in this chapter many Examples of psychotherapy given in schools and in prisons to try to give children with behavioral or prisoners in the right way, all doomed to failure. He even cites studies showing that prisoners who could benefit from psychotherapy are more likely to reoffend than those who had no treatment!

Studies show that our DNA plays a greater role in shaping our personality and our behavior as education (p51 ff). Eg by the rate of alcoholism among children of alcoholics varies little, whether the child is was educated by the alcoholic parent or adoptive parents.

Chapter 4: Why drugs do not cure the dyslogie

After the failure of psychotherapy, Rimland analyzing the failure of drug treatments. He cites several examples, first of all murders or suicides that occurred in the days occurring after the administration of some antipsychotic drugs to children. Antipsychotic drugs that were administered by physicians to notify parents of any risks. Since then, they have received "black label" warning against use in children, but yet they continue to be used in the U.S.. He cited the risk of cardiac arrest or arrhythmia due to the use of stimulants like Ritalin (over-used in the U.S.).

Illegal drug use could be justified if they were followed by real progress with behavioral problems, but on page 66 and 67 he quotes a series of murder or attack with firearms in American schools made by children ... who were taking Ritalin or other drugs. It stresses the need to consider that these crimes have occurred following the use of these drugs and not in spite of the use thereof. It criminalized

no drug use in all circumstances, but only abu thereof, which is evident in the USA, and their use without taking necessary precautions, such as "quick fix" miracle when it is not and by concealing the dangers real and cons indications yet that it does not bother to explain to the patient or relatives thereof.

Part II: the leaders of the dyslogie

Chapter 5: dyslogie food: why what your child eats can make her sad, mad or violent

It may seem strange to think that our actions or behavior are influenced by salad we ate last night or the burger? But it's true, because the food provided all the nutrients that build everything from the cells of our brain neurotransmitters until it uses to transmit messages.

The problem may be genetic and clear as in the case of phenylketonuria, but mostly the dyslogie food comes from a diet low in nutrients, combined with a genetic vulnerability. The typical American meal is doing to create the dyslogie, somehow, since it is almost empty or filled with nutrients and non nutrients or anti-nutrients such as artificial colors, sugar, additives, preservatives, etc..

Dr. Rimland also noted that if one advises mean intakes of nutrients daily, these tips apply to an "average" person but in reality that those zinc requirements may vary from 1.2 to 11.4 micrograms per cubic centimeter blood, vitamin A requirements may vary from one to ten times depending on the individual, etc..

He cites the example of the Appleton School: This school was one of the most difficult of his county, with a very high rate of violence, a policeman stationed permanently in the establishment to try to restore order, and everything went from bad to worse. Until the day when the director decided to replace school meals that were composed of pizzas, hamburgers, sodas, etc. (which is common in the U.S.) by eating "healthy." After a few months the number of problems has dramatically declined in the facility, students have become more attentive and their academic performance has improved, so Appleton became a model school, and several other district schools have followed suit with the same results.

He also cites the case of food intolerance: when certain foods, good for most people, have negative effects on others, such as strawberries, milk, wheat etc..

In the "Food and the brain of the fetus," he also cites the importance of maternal nutrition in the developing infant brain, and physical development as well. The case of folic acid is well known, however, between when a doctor discovered the relationship between folic acid deficiency of the mother and neural tube defects, several decades elapsed before the discovery is commonly accepted.

Chapter 6: The contaminated brain: how the toxicity of our environment influences the thinking of our children.

In this chapter he shows with numerous examples of any problems that may result from our toxic environment (heavy metals, pesticides, etc.). He cites the case of George Michael Hodges, who grew up in the 50s in a poor area of Appalachia. His parents were alcoholics chronically underemployed. Hodges found his toys and even food in the city dump heavily polluted bathing in a river contaminated with cyanide, manganese, lead, mercury and cadmiun. At the age of 29 years Betty Ricks he killed simply because she refused to respond to his advances. Rimland concluded that in its behavior can be attributed to a combination of factors: his impoverished childhood and his upbringing by abusive parents, as well as his poor diet, excessive toxins in the environment, and also the genetic heritage of his parents . This site

all toxic substances to which we may be exposed: pesticides in our gardens (or rivers), household products, heavy metals etc., which young children, except that they crawl and do everything in their mouths, are more exposed than we plus the fact that their developing brains are more fragile than ours.

The major threats to our children's brains are

- Endocrine: as biphenol A or phthalate, used in plastics. They are linked to cancer, birth defects, fertility problems, and changes in the brain that can alter our behavior

- Pesticides: many are endocrine disruptors that may interfere with acetylcholine, One of the main neurotransmitters involved in learning and memory.

- Alcohol: he site fetal alcohol syndrome that has devastating consequences on the child.

- Tobacco: pregnant women who smoke increase the risk of hyperactivity, impulsivity, aggression, delinquency, lower intelligence in their children etc.

- Lead: mainly through the water, despite the precautions taken in recent years

- The mercury via vaccines, although thimerosal is banned since 2002 in the U.S. vaccine, he remains in the flu vaccine

- Cadmium: he site where James Huberty killed 21 people who in a McDonalds and according to the autopsy rate was much cadmium elevated in the brain that the doctor wondered how he had to be alive

- The manganese present in the milk of breast milk substitutes (soy formula)

Chapter 7: dyslogie caused by physicians and other treatments that damage He cites brain

vaccines that are administered increasing rates and numbers of increasingly important. And also the fact that all research that challenge are deliberately ignored show buried. He also cites the case of researchers receiving intimidation or threats to conduct such research.

He criticizes the medicalization birth, with more and more drugs as cytotec administered to accelerate the work, despite the risks of such drugs or Demerol, a painkiller administered which can cause respiratory problems in babies. The ultrasonds, used increasingly in pregnancy are not without risks.

Finally he talks about the role of antibiotics in the development of diseases such as autism.

Chapter 8: Why NO case is hopeless dyslogie

For over 30 years he is involved in autism and it confirms that if 30 years ago most children with autism were institutionalized, in recent years more and more children treated with approaches similar to that advocated by DAN doctors see their improvement and development come to recover and become healthy adults leading productive lives. But

approaches Orthomolecular medicine can be used successfully in many psychiatric disorders considered. He cites the example of a child who is 3 years old had killed his hamster, 4 killed the family cat just to see if he would scream loudly, 5 had tried to kill himself by jumping from car on and intersecting throat with a knife, had bitten his sister who had to be hospitalized, etc.. Treated by Dr. Walsh, the Pfeiffer Center, a clinic specializing in orthomolecular medicine for behavioral disorders, this guy has totally lost his behavioral problems.

Chapter 9: an action plan to end the dyslogie

It is different recommendations to parents, educators and professionals. I only mention the "action plan" for parents:

  • Find a doctor practicing alternative medicine (homeopathy, naturopathy, orthomolecular medicine). Avoid doctors who abuse drugs or psychotherapy
  • Clean child's environment: water, air, soil. Avoid pesticides and other hazardous household products. Choose "green" products.
  • Provide a balanced diet and healthy child and remove the junk food (food trash style fast food, soft drinks etc.) and vitamins if appropriate.
  • Be sure your child has done in sport and physical exercise daily, and is not always locked inside
  • If necessary make a cognitive therapy, or ABA, which teach the child strategies to cope with life's problems
  • If you are pregnant: avoiding toxins, eating properly and avoid unnecessary medical procedures that may harm the fetus.

In conclusion to respond to those who reject these approaches without even thinking, he said (among other):

- The usefulness of lithium in psychiatry was discovered in 1940 but ignored for several decades

- The doctor who discovered that most ulcers were caused by a bacterial infection was denied the right to speak at medical conventions and was shunned by his colleagues - until irrefutable proof of its correctness theories are made

- The doctors who have discovered the benefits of folic acid for pregnant women have been ignored for decades, while that children still nascent to suffer and be disabled for life

My comment:

I was several times in the U.S. and I was often struck by the number of obese, especially youth. It is not uncommon to see a 20 year old walking with a cane to support his weight, see completely wheelchair. The medical profession now accepts readily the physical consequences of an unbalanced diet. In France the standard soda vending machines were removed from schools, there is now warnings on food advertising etc.. In short, it is recognized as a major health problem. We can also readily admit that an unbalanced diet can cause fatigue, lack of physical tone. Yet the idea that food can influence our behavior most recoil. Yet these same people drink coffee every morning to wake up and be more attentive. This does not prevent that some people can drink several cups of coffee at 17h and sleep without problems while other did not sleep at night if they take a cup in the afternoon. Coffee is a stimulant, but it acts differently in different individuals. But when one suggests that chocolate may cause eg a reduction in attention in a child, we always seem to look like a Martian. Why? Why is it so difficult to admit that the food has a role not only for our physical well being but for our mental well being? And the drastic change of diet during the last 50 years can only have an influence on our brain?

It also admits readily that pollution alters the ecological balance of the planet, a pollutant in a river can kill thousands of fish. And therefore in large quantities, pollutants, heavy metals that are now part of our everyday life, can have serious consequences on our health. But why is it absurd to think that these same pollutants and heavy metals in smaller quantities may also have insidious effects on our mental as physical well-being?